Our goal: medicines with broad activity for large patient populations

IMM-1-104: aims for pan-KRAS/NRAS activity against tumors driven by any mutation in KRAS or NRAS

14

Years in business

2

Therapeutic Areas

48

Publications
Immuneering’s lead product candidate IMM-1-104 aims to achieve pan-KRAS/NRAS activity while sparing normal healthy cells by driving deep cyclic inhibition of the MAPK pathway. Our earlier stage programs include six novel drug programs for patients with solid tumors and two that seek to bring precision medicine to patients with Alzheimer’s disease.

Pipeline

Immuneering is advancing a robust pipeline of novel drug programs starting with IMM-1-104, which is designed to achieve pan-KRAS/NRAS activity through deep, cyclic inhibition of MEK. This differentiated approach aims to deprive tumor cells of the sustained proliferative signaling required for rapid growth, while providing a cadenced, basal level of signaling designed to spare healthy cells.

Platform

Consistent with our approach of weaving bioinformatics and computational biology into every stage of the drug development process, we have developed a proprietary disease-agnostic platform that allows us to leverage human biological data in new and creative ways providing counterintuitive insights that are not constrained by the inherent limitations of conventional approaches or prevailing scientific views.

Publications

Our commitment to rigor and reproducible data analysis is validated by a long track record of peer-reviewed publications. Our research has been featured in a number of high impact journals and presented at medical conferences.

Head-to-head comparison of the dual-MEK inhibitor IMM-1-104 versus binimetinib in NRAS mutant melanoma models

Virtual poster released on Jan 6, 2022
Presenter: Peter King, Ph.D., Immuneering Vice President, Head of Discovery