pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model
Huntington disease (HD), a devastating hereditary neurodegenerative disorder, is caused by an expansion of a CAG trinucleotide repeat that...
Transformative Medicines Driven by Bioinformatics
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Publications
Immuneering is applying bioinformatics to forge a new approach to drug discovery, develop transformative medicines and help others make the most of their data.
Services
Our services team is second-to-none in bioinformatics and computational biology, helping world-class pharmaceutical and biotechnology companies gain actionable insights from robust, in-depth analyses of high-throughput molecular data. Our partners benefit from our decade of experience helping to characterize drug mechanisms, identify targets, pinpoint biomarkers and more.
Publications
Our commitment to rigor and reproducible data analysis is validated by a long track record of peer-reviewed publications. In collaboration with our partners in pharma and the scientific community, our research has been featured in a number of high-impact journals.
Publications
The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of...
Although substantial concerns about the inflammatory effects of engineered nanomaterial (ENM) have been raised, experimentally assessing toxicity of various...
CD38-targeted antibody, daratumumab, is approved for the treatment of multiple myeloma (MM). Phase 1/2 studies GEN501/SIRIUS revealed a novel...
Computational prediction models for assessing endocrine disrupting potential of chemicals
Endocrine disrupting chemicals (EDCs) mimic natural hormones and disrupt endocrine function. Humans and wildlife are exposed to EDCs might...
Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the...
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which impacts subsequent binding...
Loss of the Sigma-1 receptor disrupts pridopidine-induced gene expression
Objective: Investigate the role of S1R in the mechanism of action of pridopidine. Background: Sigma-1 receptor (S1R) is an...
Integrity, standards, and QC-related issues with big-data in pre-clinical drug discovery
The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug...
A meta-metastasis analysis identifies pan-cancer markers and therapeutic targets
Metastasis is a leading cause of cancer-associated deaths across several cancer types, yet the molecular details of its development...
