Mr. Amin joins Immuneering after having built a strong track record for nearly two decades on Wall Street covering small and mid-cap biotechnology companies focused on oncology, central nervous system disorders, ophthalmology, and rare diseases. Prior to Immuneering, Mr. Amin spent nearly 10 years at Jefferies as Managing Director of Biotechnology Research. Previously, he spent time at other equity research firms such as WJB Capital Group, FTN Equity Markets, Stanford Financial, and Prudential Equity Group. Mr. Amin started his career at Aventis Pharma where he was Senior Manager in their scientific competitive intelligence group with business development. He holds an M.B.A. from Stern School of Business at New York University, a M.S. in Pharmacy from Long Island University, and a B.S. in Pharmacy from University of the Sciences in Philadelphia.
Dr. Armoskus combines experience in the field of neurobiology with the techniques of computational biology and bioinformatics. He earned his Ph.D. in Biostatistics from the Keck School of Medicine at USC while doing research at the Zilkha Neurogenetic institute. His thesis demonstrated important transcriptional differences in schizophrenia and developed a novel algorithm for the analysis of differential expression in RNA-Seq data. He works on the analysis of neurodevelopmental and neurodegenerative conditions at the genomic, transcriptomic, and epigenetic levels.
Ms Axel is a highly skilled scientist with experience in academia (Nationwide Children's Hospital, Ohio, USA) and the pharmaceutical industry (Janssen/J&J in Belgium and USA). She has expertise in solid and hematologic tumors focusing on physiologically relevant models for tumor microenvironment and complex cell‐based assays to evaluate molecules with varying mechanisms of action. Moving from directing hypothesis driven biomarker research projects, internally and externally, Ms Axel transitioned to an operational role at Janssen executing biomarker strategies in clinical trials in early development. She graduated from Ohio State University with a BSc. in Molecular Genetics.
Dr. Barrett is an accomplished medical oncologist and R&D expert with more than 30 years of clinical and research experience in leadership positions at major institutions in industry and academia. He has spent the last decade gaining broad expertise in the fields of target and drug discovery, most recently, as executive director/ lead of global medical affairs for targeted oncolytic therapies at Incyte Pharmaceuticals. Dr. Barrett is a trained physician-scientist, earning his bachelor’s degree at The Johns Hopkins University as a Beneficial-Hodson Scholarship recipient. He then earned his medical degree from the University of Miami School of Medicine and completed his internal medicine residency at the Mayo Clinic in Rochester, Minn. At Memorial Sloan-Kettering Cancer Center, Dr. Barrett completed his fellowship in medical oncology where he co-authored a Phase 2, proof-of-concept study, which pioneered the use of paclitaxel for advanced breast cancer treatment in the ambulatory setting. Prior to entering the biopharmaceutical industry, he practiced academic and community-based hematology/oncology for 15 years. Dr. Barrett is board-certified in both internal medicine and in medical oncology.
Dr. Battula is a highly passionate scientific leader with expertise in the areas of immuno-oncology (IO), inflammation and autoimmunity. She is an experienced scientist previously leading projects at Applied Immunology, FORMA Therapeutics, Inc. and most recently as associate director of immuno-oncology at Bicycle Therapeutics. She performed postdoctoral research at U.C. San Francisco after earning her Ph.D. in Pharmacology from New York Medical College.
Dr. Brothers is a Bioinformatician with expertise in NGS data analysis and specializes in transcriptomics. He brings industry experience with working in team-based collaborative environments with clinicians, experimentalists, and bioinformaticists. He graduated with a B.S. in Bioinformatics from the Rochester Institute of Technology and a Ph.D. in Bioinformatics from Boston University. His doctoral thesis focused on identifying splice variants and novel genes associated with chronic lung disease in order to better characterize the lung transcriptome from patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis.
Since joining Immuneering, Ms. Cha has developed an expertise in multi-omic integration and mutation prioritization in cancer data. She holds a B.S. in Computer Science and Molecular Biology from the Massachusetts Institute of Technology. Before graduating, she spent a year at the Bioinformatics Institute at Seoul National University working on a method to identify differentially expressed signaling pathways. She also spent a summer at the Robert Koch Institute in Berlin, Germany, analyzing genomic and proteomic data from viruses. She won first place in the 10th Annual Merck/BE-BMES Undergraduate Research Poster Session.
Dr. Escalante-Chong is passionate about integrating the massive amounts of data generated in modern biology to transform disease management and treatment. He did his Ph.D. at the Department of Systems Biology at Harvard Medical School where he used quantitative molecular genetics to dissect signaling pathways. He completed his postdoctoral training at the Department of Biological Engineering at the Massachusetts Institute of Technology where he worked with the interdisciplinary teams of neuroLINCS and answerALS to generate molecular signatures of the neurodegenerative diseases ALS and SMA.
Dr. Fowler brings deep expertise in biology and computational biology to our team. He joined Immuneering after completing his Ph.D. in Chemical Engineering at the Massachusetts Institute of Technology. His doctoral research was focused on computational immunology and signal integration in immune cell biology, and he conducted research at Harvard Medical School.
Dr. Funt’s focus is in synthesizing actionable insight from complex, heterogeneous high-dimensional data. He earned his Ph.D. in Computational and Systems Biology from MIT’s Biology Department. His thesis research, at both the Massachusetts Institute of Technology and the Broad Institute, focused on mapping evolutionary pathways of drug resistance from genomic and transcriptomic profiling of the pathogen Candida albicans.
Dr. Rizo has a strong track record in the global biotechnology and pharmaceutical industries, building out commercial capabilities that maximize profitability and create long-term partnerships in oncology, immuno-oncology (I/O) and neurological diseases. Prior to joining Immuneering, Dr. Rizo was chief business officer at Just Biotherapeutics, where she was responsible for business development, strategy and finance leading to the acquisition by Evotec. Dr. Rizo also previously served as global managing director of strategic partnerships for Thermo Fisher Scientific, where she led global business development and commercialization of next generation sequencing (NGS)-based companion diagnostics contributing to the company’s leadership in precision medicine. She previously held leadership positions in business development and technology commercialization at Roche, Cepheid and Massachusetts Institute of Technology (MIT). Dr. Rizo earned her Ph.D. in atomic and molecular physics and conducted research at the Spanish National Research Council (CSIC), the French National Centre for Scientific Research (CNRS) and University of California Berkeley, where she was a Fulbright Scholar. She completed her MBA at MIT Sloan School of Management in Cambridge, Mass.
Dr. Gutierrez is a highly motivated, results-driven clinical research leader with medical background and about 20 years of experience in clinical drug development. Her research experience involves variety of investigational products (small molecule, cellular therapies, devices) and therapeutic areas, with focus on early phase Oncology. She combines deep industry knowledge with a proven track record of clinical trials execution across multiple functions. Dr. Gutierrez gained her MD degree in Smolensk State Medical Academy (Russia), and entered the biopharmaceutical industry after completing her clinical residency in internal medicine and fellowship in cardiology. She spent over 10 years working at the clinical CROs, including Pharm-Olam International and Sarah Cannon Development Innovations. Most recently, Dr Gutierrez has been leading Clinical and Safety Operations at Bellicum Pharmaceuticals, Houston-based biotech company focusing on cellular therapies.
Dr. Hall is a pharmaceutical and biotechnology veteran (Janssen/J&J; Medimmune/AZ, Molecular Response; Asellus Therapeutics) with extensive drug development and leadership experience ranging from early drug discovery through translational clinical sciences including multiple drug registrations. He was the translational lead for Sylvant® (siltuximab) and Imbruvica® (ibrutinib) throughout clinical development, and his translational medicine teams developed and executed translational strategies for both Darzalex® (daratumumab) and Imfinzi® (durvalumab). Dr. Hall has extensively published in the areas of tumor microenvironment (TME) and translational sciences and holds multiple patents for drug pharmacology and discovery. Prior to his experience in the life sciences industry, Dr. Hall served in the United States Air Force and worked as a Series 6 and 63 licensed investment banker. After completing his graduate and postdoctoral studies, Dr. Hall was a tenure-track assistant professor at Ohio State University where his laboratory focused on development of human TME-aligned models to better translate preclinical data into the clinic and discover novel biomarkers.
Ms. Iodice brings with her extensive clinical trials experience with expertise in immune-oncology, medical oncology and neurological surgery. She has worked in major medical academic centers in both clinical and research positions as well as Industry. Most recently working in clinical development for a small biotech company that is developing oncolytic viruses for solid tumors. She holds a BA in Psychology and a BSN in Nursing.
Dr. Kagalwala straddles neuroscience R&D and business leadership experience to develop innovative therapeutics for aging neurodegenerative disorders. He has extensively published high impact research in peer-reviewed journals. Prior to joining Immuneering, he co-founded Siragen Pharmaceuticals, where he led the small molecule drug discovery program for Alzheimer’s disease, from target identification through proof of concept, and lead optimization. Dr. Kagalwala completed his Ph.D. in Biochemistry at SIU School of Medicine (dissertation on chromatin remodeling), and then post-doctoral training at MD Anderson Cancer Center (Glioblastoma / Medulloblastoma), and the Salk Institute (adult neurogenesis and neurodegeneration). In 2015, he also earned an MBA at Rady School of Management, UC San Diego, where he was awarded the prestigious Foster fellowship, and recognized as a Rady Innovation Fellow for business assistance to technology acceleration and commercialization programs.
Dr. Kaufman is a leading authority on tumor immunotherapy with a distinguished career in academia and industry. His major accomplishments include pioneering work to develop the first oncolytic virus approved for the treatment of advanced melanoma and a novel programmed cell death ligand 1 (PD-L1) inhibitor as the first drug ever approved for the treatment of patients with Merkel cell carcinoma. Dr. Kaufman has published more than 500 peer-reviewed abstracts, scientific/clinical manuscripts and book chapters. His industry leadership roles have included scientific and advisory boards at Amgen, Bristol-Myers Squibb, EMD Serono/Merck KGaA, Merck, Sanofi and he served as chief medical officer at Compass Therapeutics and Replimune, Inc. His academic leadership includes service as director of the Rush University Cancer Center and was chief of the division of surgical oncology and associate cancer center director at Columbia University as well as the Rutgers Cancer Institute of New Jersey. He held the Weiskopf endowed associate professorship at Columbia University and was tenured full professor at Rush Medical School and Rutgers University. His professional contributions include major leadership roles at the American Cancer Society, American Association of Cancer Research, American Society of Clinical Oncology, Commission on Cancer, Society of Surgical Oncology and the Society for Immunotherapy of Cancer and has served as President. Dr. Kaufman has been the recipient of several awards, including the Daland Prize, the Humanitarian Award of the Melanoma Research Foundation and the UIC Distinguished Alumnus Award. Dr. Kaufman is board certified and maintains a small clinical practice at the Massachusetts General Hospital. He also has an appointment at the Harvard Medical School.
Mr. Kim is passionate about utilizing technology to accelerate research and development in the field of biomedicine. Prior to obtaining his M.S. in Biomedical Informatics from the Sackler Institute of Graduate Biomedical Sciences at NYU School of Medicine, he spent over five years working as a software implementation consultant specializing in the life sciences industry, where he led projects to configure, deploy, and manage the enterprise software development life cycle. He also graduated with a B.S./M.S. in Biomedical Engineering from Northwestern University.
Dr. King is a pharmaceutical professional with over 16 years of drug discovery and development experience (Janssen R&D/Johnson & Johnson; SmithKLine Beecham). With experience ranging from early drug discovery and preclinical/translational sciences. Dr King gained his B.Sc. from the University of Leicester, UK, in Biological Sciences in 1996, and his Ph.D. in Diabetes and Endocrinology in 2000, from the University of Liverpool, UK. After 2 years of postdoctoral training, Dr King joined Janssen Pharmaceuticals in 2002 at the Beerse site in Belgium, as a Scientist and Senior Scientist, in the Metabolic Disorders and Oncology Teams. He led the preclinical oncology in vivo team, where he contributed to numerous NME declarations and IND filings. As part of the Oncology Biomarkers Team, he was responsible for the Ex Vivo Center of Excellence for humanized model development. In 2012, Dr King joined the Molecular Imaging Team at the Janssen Spring House site in USA and lead the imaging program to support the Oncology Therapeutic Area.
Dr. Kolitz brings expertise in teasing apart biological mechanisms to our team. She conducted her postdoctoral research in Biological Engineering at the Massachusetts Institute of Technology, after earning a Ph.D. in Biophysics and Biophysical Chemistry from the Johns Hopkins University School of Medicine.
Dr. Krishnan brings expertise in understanding cellular responses to protein misfolding events and developing therapies to mitigate toxicity associated with these conditions. Over the last decade he was involved in designing Ig-fusion-based therapeutics to treat Alzheimer’s disease and Systemic Amyloidosis. Prior to joining the biotech industry, he conducted his postdoctoral research at the Whitehead Institute of Biomedical Research (MIT) and earned a PhD in Biophysics and Molecular Biology from the Center for Cellular and Molecular Biology, Hyderabad, India.
Dr. Kusko is a computational biologist with expertise in translating NGS and other genomic data to clinical discoveries and actionable insights. In five years at Immuneering, Dr. Kusko has published 14 journal articles and three textbook chapters spanning best practices, neurodegeneration, oncology, computational toxicology, drug mechanism of action and biomarker development. She is a founding member and current deputy board chairperson of the FDA-led Massive Analysis and Quality Control (MAQC) Society. Dr. Kusko has integrated directly with clinicians on study design, as well as with lab scientists in functional genomics, to plan molecular biology and validation experiments. After completing her undergraduate degree in biological engineering at the Massachusetts Institute of Technology (MIT), she went on to complete her Ph.D. in computational biomedicine at the Boston University School of Medicine where her doctoral thesis focused on the transcriptome in chronic obstructive pulmonary disease (COPD) and lung cancer in never-smokers. Dr. Kusko is a guest lecturer at MIT and Boston University.
Dr. Lysaght integrates years of experience with biological expression data together with a rigorous background in engineering fundamentals to provide expertise in customized data analysis with an eye for practical and actionable results. He earned a Ph.D. from the joint Harvard-MIT Program in Health Sciences and Technology, where he worked alongside leading clinicians of the Massachusetts Eye and Ear Infirmary to identify changes in inner ear transcription and translation during delayed onset hearing loss.
Ms. Martin has several years of experience in office administration in various industries, as well as a broad background in customer relations, social media and marketing, human resources and recruiting, and finance. She holds a B.S. in Communications from Fitchburg State University.
Dr. Obla is a computational biologist with diverse experience in the field of genomics. He received his PhD in Molecular Cell Biology from University of Connecticut. His doctoral work involved the study of ribosomal protein gene family evolution in mammals and development of a novel classifier for single cell RNA seq library QC. He then worked as a bioinformatician for four years at the Mount Sinai Hospital (MSH) in NYC, contributing primarily to their pathogen surveillance initiative. Dr. Obla’s work at MSH involved assembling high quality genomes of various bacterial & viral pathogens followed by integration with electronic medical record data to perform genomic epidemiology. Dr. Obla was also involved in various multi-omic clinical research studies at MSH.
Dr. Rajpurkar is a computational biologist with extensive experience in genomics, machine learning, and the biology of gene regulation. Her prior work includes integration of immune single cell expression datasets, algorithm development in genomics and image processing, and applying machine learning to biological problems. She earned her PhD from Stanford University School of Medicine in Genetics. Her thesis work focused on developing deep learning-based methods to understand the relationship between chromatin folding and gene regulation.
Dr. Rose is a computational biologist with experience integrating large single cell and bulk genomic datasets to address problems relating to public health, stem cells, and cancer biology. He received his Ph.D. from Cornell University’s Genetics, Genomics and Development program. His thesis work focused on understanding the molecular mechanisms underlying malignant transformation in the Fallopian tube.
For over a decade, Dr. Ross studied at the National Institutes of Health, where he designed and conducted original research in the field of bioinformatics and comparative genomics. His work has been recognized for enhancing computational methods to identify and analyze molecular mechanisms that regulate neurogenesis. Dr. Ross has developed and employed machine learning and bioinformatic algorithms to decode the combinatorial logic of noncoding DNA that control gene expression programs. He earned his Ph.D. degree in Neuroscience from Brown University.
Dr. Farrah Roy (they/them) is a wet-lab molecular biologist turned bioinformatician with several years worth of experience analyzing NGS data and bioinformatics. They earned a B.A. in Biology at Wheaton College, MA. Their Ph.D thesis work - completed at Tufts Graduate School of Biomedical Sciences - focused on understanding the regulation and expression patterns of endogenous retroviruses in cancer, relying on a mixture of wet-lab and dry-lab technologies. Upon obtaining their Ph.D in Genetics, they moved on to a postdoctoral fellowship position at the Harvard T.H. Chan School of Public health, where they developed an RNA-sequencing pipeline used to identify endogenous and exogenous viral reads within a given data set. They have participated in a number of conferences to present their work, authored several manuscripts, and have collaborated on several projects involving NGS data and viral detection.
Dr. Shrimali is an accomplished immunologist and immune therapist bringing over 15 years of expertise in the field of Immuno-Oncology (IO). His research interest and expertise include tumor microenvironment (TME) and immune regulation, immune check point inhibitors / co-stimulators, development of biologics and targeted cancer immune therapies and identification of clinical biomarkers. His major endeavor involves development of corrective combinational cancer therapies and delineating their cellular and molecular immune potentiating mechanism of action. His published research highlights the significance of timing and sequence of targeting various immune checkpoints and the immune context of the TME, that can determine the therapeutic outcome. He received his Ph.D. in biochemistry from Indian council of medical research, Mumbai university, India. During his postdoctoral training, he had the privilege to work with Dr. Steven A. Rosenberg at NCI / NIH, the pioneer in the field of cancer immunotherapy. Following that, he has held various scientific and leadership positions as senior scientist, group leader and Director IO at some of the most esteemed organizations including Aurigene Discovery Technologies Ltd., Peloton Therapeutics and MD Anderson Cancer Center. In above positions, he has been the immunology lead of various oncology and inflammation programs right from early target discovery through IND filing and further out licensing or patient trials of clinical candidate.
Outside work he enjoys spending time in traveling with his family, Indian cooking, stage / theater acting and hosting live radio shows.
Dr. Wang has been working on integrating computational approaches and biological data to investigate the biology underlying human diseases for over 8 years. He earned his Ph.D. in Bioinformatics from Department of Information and Communication Engineering, Huazhong University of Science and Technology, China. During his Ph.D. career, he spent two years in Genetics at Dartmouth College as a visiting scholar. His major research focus was computationally identifying novel biomarkers for predicting survival outcomes in breast cancer. During his postdoctoral research in the Department of Biomedical Data Science at Geisel School of Medicine at Dartmouth he worked on drug repositioning, novel biomarkers identification, and patients ‘intrinsic’ subsets classification in Systemic Sclerosis (SSc, a rare autoimmune disease) in the Whitfield lab. Frank then became a research scientist in the same lab and continued his computational research in SSc. He has interest and expertise in performing computational analyses in different biological data types including microarray, DNA methylation, ChIP-seq, single-cell/bulk RNA-seq, and ATAC-seq data.
Dr. Zeskind co-founded Immuneering in 2008 with the goal of leveraging high-throughput data to improve pharma R&D. He is an inventor on numerous patents assigned to both Immuneering's partners and the company itself. Dr. Zeskind has published extensively in high-impact peer-reviewed journals. He trained at the Massachusetts Institute of Technology, earning a Ph.D. in Bioengineering in 2006 and an S.B. in electrical engineering and computer science in 2003. He also earned an MBA at Harvard Business School in 2008, where he was recognized as a Baker Scholar, the highest award for distinction.
Dr. Zhang extracts actionable insights from genomic data by combining cutting-edge data science techniques with expertise in experiment design and cancer biology. During her data science fellowship at The Data Incubator, she utilized distributed computing, network analysis, and machine learning to reveal patterns within large textual and numerical datasets. She graduated from the Massachusetts Institute of Technology with a B.S. in Physics, and Duke University with a Ph.D. in Genetics and Genomics. In her doctoral work, she developed novel experimental and bioinformatic methods to generate and analyze terabytes of next-generation sequencing data towards understanding the mutational underpinnings of lymphoma.
Mr. Carpenter is a leader and pioneer in the healthcare and biotechnology industries. He served on Genzyme’s board of directors from 1994-2011 and was executive vice president of Genzyme from 1989-1991 as well as chairman of its subsidiary IG Laboratories. He founded and served in executive management and board roles at numerous biotech companies, including Integrated Genetics and GelTex Pharmaceuticals, both of which merged with Genzyme, and VacTex, which was acquired by Aquila Biopharmaceuticals. Mr. Carpenter is currently chairman of Hydra Biosciences. Mr. Carpenter is a graduate of West Point. He earned his master’s degree in computer science from Stanford University and his MBA from Harvard Business School.
Mr. Feinberg has more than three decades of experience in the financial services industry at Oppenheimer & Co. He is a founding member of Boxcar Partners, a venture capital investment firm comprised of several family offices with a focus area in biotech investing. He is a founder of multiple companies including BridgeBio, which invests in preclinical, non-public, rare genetic disease assets, North Coast Partners, a real estate holding company that invests in Detroit. He is an advisory board member of Ignite Power, an African solar energy company, currently the largest in Rwanda, which has created a life changing experience for its citizens and Sporos Bioventures. Mr. Feinberg earned his bachelor’s degree in finance from Whittier College.
Andy Phillips, Ph. D. is a Managing Director at Cormorant Asset Management, LP (“Cormorant”). Before joining Cormorant, Andy was the President and Chief Executive Officer of C4 Therapeutics, a company pioneering targeted protein degradation medicines. Prior to joining C4 Therapeutics, Andy was Senior Director, Center for Development of Therapeutics at the Broad Institute of MIT and Harvard, where he led overall therapeutic efforts and provided strategic leadership for a number of major partnerships. Previously, he was a Full Professor of Chemistry at Yale University and a Full Professor of Chemistry and Biochemistry at the University of Colorado.
Andy holds Ph.D. and B.Sc. Hons. degrees in Biochemistry and Chemistry from the University of Canterbury (Christchurch, New Zealand). His academic research and accomplishments have been recognized by a number of national and international awards including the ACS Cope Scholar Award.
Mr. Kekst is a founding member of Boxcar Partners, a venture capital investment firm comprised of several family offices with a focus area in biotech investing. He serves on the board of advisors at The Jewish Theological Seminary and is a board member at the Weizmann Institute of Science. He is also a founder of Sporos Bioventures. Mr. Kekst earned his bachelor’s degree from Brandeis University.