Rapidly Growing Pipelines of Transformative Medicines

Immuneering is developing its lead candidate IMM-1-104 as a dual inhibitor of MEK and a related target, to inhibit this important pathway driving the growth of many tumors while avoiding the feedback loop that causes many patients to develop resistance to traditional MEK inhibitors. By targeting MEK in a novel way, our preclinical models have demonstrated greater durability with reduced overall toxicity.

Our Clinical Candidate, IMM-1-104, is in IND-enabling studies.

Immuneering is developing IMM-2019611 as a differentiated inhibitor of the MAPK signaling pathway. The MAPK pathway is a central signaling cascade involved in cell proliferation, cell growth, malignant transformation and drug resistance. Increased expression of this pathway is associated with a poor prognosis in cancers.⁵

IMM-2019611 is currently in lead identification stage of drug development.

Immuneering is developing IMM-1811900 for KRAS-driven cancers including pancreatic, colorectal and lung cancers. KRAS is the most commonly mutated of the RAS isoforms and represents an attractive target for treatment given its ubiquity, central role as a driver mutation and association with poor prognosis. KRAS mutations occur in approximately 25 percent of all human cancers, including more than 90 percent of pancreatic cancers, 35 to 45 percent of colorectal cancers and approximately 25 percent of lung cancers.⁶ Activating mutations of KRAS lead to cell transformation and increased resistance to chemotherapy. Currently, no effective treatments exist that target mutant variants of KRAS.

IMM-1811900 is currently in hit-to-lead stage of drug development.