Publications
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May 21, 2018
Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
Huntington Disease (HD) is an incurable autosomal dominant neurodegenerative disorder driven by an expansion repeat giving rise to the mutant huntingtin protein (mHtt), which is known to disrupt a multitude…
Journal: Molecular Neurodegeneration
May 15, 2018
Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated through Molecular Dynamics Simulations
When a small molecule binds to the androgen receptor (AR), a conformational change can occur which impacts subsequent binding of co-regulator proteins and DNA. In order to accurately study this…
Journal: Frontiers in Pharmacology
April 18, 2018
Metastasis: Leveraging transcriptomics to identify potential therapeutics
Five-year survival rates for patients whose cancer has metastasized are dramatically lower than for those with localized disease. However, few therapeutic development efforts specifically focus on inhibiting the process of…
April 16, 2018
Cachexia: Leveraging transcriptomics to identify potential therapeutics
Cachexia is a common cause of morbidity across multiple cancer types, yet remains largely under-studied especially in the realm of transcriptomics. An essential component of cancer cachexia is the induced…
April 9, 2018
Loss of the Sigma-1 receptor disrupts pridopidine-induced gene expression
Objective: Investigate the role of S1R in the mechanism of action of pridopidine. Background: Sigma-1 receptor (S1R) is an ER chaperone protein involved in neuromodulation and neuroplasticity. Pridopidine is a…
March 15, 2018
Integrity, standards, and QC-related issues with big-data in pre-clinical drug discovery
The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug discovery and development. In the field of life sciences, the growth…
Journal: Biochemical Pharmacology
January 30, 2018
A meta-metastasis analysis identifies pan-cancer markers and therapeutic targets
Metastasis is a leading cause of cancer-associated deaths across several cancer types, yet the molecular details of its development have not been fully elucidated. Transcriptomic analysis can provide insight into…
December 9, 2017
Cachexia mechanisms in cancer through the lens of transcriptomics
Introduction: Cachexia is a major clinical complication that affects up to 80% of patients with advanced cancer, and by some estimates is responsible for 20% of cancer deaths [1]. Despite…
December 8, 2017
The international MAQC Society launches to enhance reproducibility of high-throughput technologies
Reproducibility is a fundamental hallmark of good science. The US Food and Drug Administration (FDA)-led Microarray and Sequencing Quality Control (MAQC/SEQC) consortia conducted three projects 1,2,3 to assess the reliability and…
Journal: Nature Biotechnology
December 7, 2017
Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice
Pridopidine is currently under clinical development for Huntington disease (HD), with on-going studies to better characterize its therapeutic benefit and mode of action. Pridopidine was administered either prior to the…
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